Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics

Anastasia H. Potts; Christopher A. Vakulskas; Archana Pannuri; Helen Yakhnin; Paul Babitzke; Tony Romeo

doi:10.1038/s41467-017-01613-1

Nature Communications (Nov 2017)

Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics

Anastasia H. Potts,
Christopher A. Vakulskas,
Archana Pannuri,
Helen Yakhnin,
Paul Babitzke,
Tony Romeo

Affiliations

Anastasia H. Potts: Department of Microbiology and Cell Science, University of Florida, Institute of Food and Agricultural Sciences
Christopher A. Vakulskas: Department of Microbiology and Cell Science, University of Florida, Institute of Food and Agricultural Sciences
Archana Pannuri: Department of Microbiology and Cell Science, University of Florida, Institute of Food and Agricultural Sciences
Helen Yakhnin: Department of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park
Paul Babitzke: Department of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park
Tony Romeo: Department of Microbiology and Cell Science, University of Florida, Institute of Food and Agricultural Sciences

DOI: https://doi.org/10.1038/s41467-017-01613-1
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

Read online

The RNA-binding protein CsrA regulates the expression of hundreds of bacterial genes. Here, Potts et al. use several approaches to assess the contribution of CsrA to global gene expression in E. coli, revealing new binding targets and physiological roles such as in envelope function and iron homeostasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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