Deciphering the effects of STN DBS on neuropsychiatric fluctuations in Parkinson’s disease

Mari Muldmaa; Emmanuelle Schmitt; Roberto Infante; Andrea Kistner; Valérie Fraix; Anna Castrioto; Sara Meoni; Pierre Pélissier; Bettina Debû; Elena Moro

doi:10.1038/s41531-024-00811-1

npj Parkinson's Disease (Oct 2024)

Deciphering the effects of STN DBS on neuropsychiatric fluctuations in Parkinson’s disease

Mari Muldmaa,
Emmanuelle Schmitt,
Roberto Infante,
Andrea Kistner,
Valérie Fraix,
Anna Castrioto,
Sara Meoni,
Pierre Pélissier,
Bettina Debû,
Elena Moro

Affiliations

Mari Muldmaa: Grenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience
Emmanuelle Schmitt: Grenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience
Roberto Infante: Grenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience
Andrea Kistner: Grenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience
Valérie Fraix: Grenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience
Anna Castrioto: Grenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience
Sara Meoni: Grenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience
Pierre Pélissier: Grenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience
Bettina Debû: Grenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience
Elena Moro: Grenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience

DOI: https://doi.org/10.1038/s41531-024-00811-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 6

Abstract

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Abstract The impact of subthalamic nucleus (STN) deep brain stimulation (DBS) on neuropsychiatric fluctuations in Parkinson´s disease (PD) remains unclear. The Neuropsychiatric Fluctuations Scale (NFS) can help to fill this gap, directly measuring fluctuations between the OFF- and ON-medication conditions. The NFS provides NFS-plus (hyperdopaminergic) and NFS-minus (hypodopaminergic) sub-scores. Based on these, the NFS global scores express the overall magnitude of neuropsychiatric symptoms in both the OFF- and ON-medication states. The total fluctuation score (TFS) represents the difference between ON- vs. OFF-medication NFS global scores, thus assessing fluctuations amplitude. The NFS was used to evaluate changes in neuropsychiatric fluctuations between the OFF- and ON-medication conditions before and 1-year after bilateral STN-DBS in 45 PD patients (32 males; mean age, 61.3 ± 7.2 years; PD duration, 10.2 ± 3.0 years). After surgery, the amplitude of neuropsychiatric fluctuations was significantly reduced (p < 0.001), confirming the efficacy of STN-DBS on these symptoms.

Published in npj Parkinson's Disease

ISSN: 2373-8057 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.nature.com/npjparkd/

About the journal