Human amniotic epithelial cells exert anti-cancer effects through secretion of immunomodulatory small extracellular vesicles (sEV)

Mohammad-Reza Bolouri; Roya Ghods; Kayhan Zarnani; Sedigheh Vafaei; Reza Falak; Amir-Hassan Zarnani

doi:10.1186/s12935-022-02755-z

Cancer Cell International (Oct 2022)

Human amniotic epithelial cells exert anti-cancer effects through secretion of immunomodulatory small extracellular vesicles (sEV)

Mohammad-Reza Bolouri,
Roya Ghods,
Kayhan Zarnani,
Sedigheh Vafaei,
Reza Falak,
Amir-Hassan Zarnani

Affiliations

Mohammad-Reza Bolouri: Department of Immunology, Iran University of Medical Sciences
Roya Ghods: Oncopathology Research Center, Iran University of Medical Sciences
Kayhan Zarnani: Department of Immunology, School of Public Health, Tehran University of Medical Sciences
Sedigheh Vafaei: Biotechnology Research Center, Avicenna Research Institute, ACECR
Reza Falak: Department of Immunology, Iran University of Medical Sciences
Amir-Hassan Zarnani: Department of Immunology, School of Public Health, Tehran University of Medical Sciences

DOI: https://doi.org/10.1186/s12935-022-02755-z
Journal volume & issue: Vol. 22, no. 1
pp. 1 – 18

Abstract

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Highlights Anti-cancer effects of hAEC depend on cancer type. Cross-reactive humoral responses do not mediate anti-cancer effects of hAEC. Anti-cancer effects of hAECs are mainly mediated by small-extracellular vesicles (sEV). hAEC-derived sEV (AD-sEV) trigger the Warburg’s effect leading to Arginine consumption and cancer cell apoptosis. AD-sEV substantially inhibits tumor development and increases survival and CTL responses.

Published in Cancer Cell International

ISSN: 1475-2867 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: https://cancerci.biomedcentral.com

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Abstract

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