DYNAMIC CHANGES OF CHEMOKINE CXCL-10 (IP-10) IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS

Abstract

CXCL10 (IP-10) chemokine is one of additional humoral markers applied along with determination of antigen-induced IFNγ for diagnosis of latent tuberculosis infection in humans. Dynamics of the IP-10 changes and its prognostic value in planning treatment for various forms of tuberculosis is a scarcely studied problem, especially, in children and adolescents. Present study has revealed an increase in spontaneous and antigen-induced IP-10 production in children and adolescents with overt tuberculosis, when compared with latent course of tuberculosis, followed by its significant reduction in cases of successful chemotherapy of tuberculosis. Such dynamics was not evident in destructive forms of tuberculosis manifesting as torpid and progressive infection.

Keywords

• tuberculosis
• children
• adolescents
• chemokines