Identification and Semi-Synthesis of 3-<i>O</i>-Protocatechuoylceanothic Acid, a Novel and Natural GPR120 Agonist <xref rid="fn1-molecules-602982" ref-type="fn">†</xref>

Abstract

The identification and three step synthesis of 3-O-protocatechuoylceanothic acid, a novel and natural GPR120 agonist, is described. This ceanothane-type triterpenoid was identified from the components of Ziziphus jujuba roots and was found to be a new GPR120 agonist with a novel structure. We synthetically converted ceanothic acid, which does not have GPR120 agonist activity, into 3-O-protocatechuoylceanothic acid in three steps. In addition, we present the corrected NMR spectrum of 3-O-protocatechuoylceanothic acid based on our synthesis.

Keywords

• g protein-coupled receptor
• gpr120
• agonist
• 3-<i>o</i>-protocatechuoylceanothic acid
• semi-synthesis