Clinical and Applied Thrombosis/Hemostasis (Oct 2019)

The Utility of the Lipoprotein-Associated Phospholipase A (Lp-PLA) Assay in Detecting Abnormalities in Lipid Metabolism and Cardiovascular Risk in an HIV-Infected South African Cohort

  • Elizabeth S. Mayne MD,
  • Hellen Moabi MD,
  • Diederick E. Grobbee MD,
  • Roos E. Barth MD,
  • Kersten Klipstein-Grobusch MD,
  • Wendy S. Stevens MD,
  • Alinda G. Vos MD,
  • Susan Louw MD

DOI
https://doi.org/10.1177/1076029619883944
Journal volume & issue
Vol. 25

Abstract

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People with HIV (PWH) have an increased prevalence of cardiovascular disease (CVD) compared to uninfected patients. Lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) catalyzes the synthesis of pro-inflammatory lipids that recruit monocytes. Current guidelines for assessing cardiovascular risk in HIV-infected patients suggest that Lp-PLA 2 may be a useful surrogate marker for CVD health in this patient population. Lipoprotein-associated phospholipase A 2 , lipids, glucose, physical parameters, and carotid intimal–medial thickness (CIMT) were measured in 98 participants (49 HIV-uninfected, 27 antiretroviral therapy [ART]-naive PWH, and 22 ART-treated PWH). HIV viral load (VL) and CD4+ T-cell count were measured in HIV-infected participants. Lipoprotein-associated phospholipase A 2 was increased in participants on protease inhibitor (PI) ART (median 50.5 vs 127.0 nmol/mL, P = .05) and correlated with age, body mass index, and cholesterol. Lipoprotein-associated phospholipase A 2 was not related to Framingham risk score or CIMT but correlated directly with VL ( r = .323, P = .025) and inversely with CD4+ T-cell count ( r = −.727, P < .001). Lipoprotein-associated phospholipase A 2 was increased in HIV-infected participants on PIs and correlated strongly with VL and CD4+ T-cell count suggesting that HIV-associated inflammation is linked to increased Lp-PLA 2 , providing a mechanistic link between HIV and CVD.