High free triiodothyronine, and free-triiodothyronine-to-free-thyroxine ratio are associated with metabolic syndrome in a euthyroid employee population: the Zhejiang Zhenhai study

Qiankai Jin; Guoqing Huang; Xiaoqing Tian; Yimeng Shu; Ximisinuer Tusongtuoheti; Yushan Mao

doi:10.1530/EC-22-0424

Endocrine Connections (May 2023)

High free triiodothyronine, and free-triiodothyronine-to-free-thyroxine ratio are associated with metabolic syndrome in a euthyroid employee population: the Zhejiang Zhenhai study

Qiankai Jin,
Guoqing Huang,
Xiaoqing Tian,
Yimeng Shu,
Ximisinuer Tusongtuoheti,
Yushan Mao

Affiliations

Qiankai Jin: Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China; School of Medicine, Ningbo University, Ningbo, China
Guoqing Huang: Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China; School of Medicine, Ningbo University, Ningbo, China
Xiaoqing Tian: Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China; School of Medicine, Ningbo University, Ningbo, China
Yimeng Shu: Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China; School of Medicine, Ningbo University, Ningbo, China
Ximisinuer Tusongtuoheti: Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China; School of Medicine, Ningbo University, Ningbo, China
Yushan Mao: Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China

DOI: https://doi.org/10.1530/EC-22-0424
Journal volume & issue: Vol. 12, no. 5
pp. 1 – 12

Abstract

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Objective: The aim of this study was to elaborate the link of thyroid hormones (THs) and metabolic syndrome (MetS) in a Chinese euthyroid employee popul ation with MetS component(s). Methods: An annual health checkup was performed on employees in 2019. Anthropometric parameters, metabolic parameters, and thyroid function were measured. A questionnaire was used in conjunction with Zhenhai Lianhua Hospital database to receive employees' medication records and thyroid s urgical history records. Results: A total of 5486 eligible employees were included; the prevalen ce of MetS was generally higher in males than in females (38.9 vs. 30.4%, P < 0.001). Among employees with central obesity, hypertriglyceridemia, hyperglycemia, hypertension, and low high-density lipoprotein cholesterol (HDL-C), the prevalence of MetS was 68.8, 63.6, 68.2, 48.8, and 60.0% in males and 72.6, 63.3, 61.3, 42.3, and 42.3% in females, respectively. Logistic regression analysis showed that thyroid-stimulating hormone and free thyroxine (FT4) quartiles had no significant impact on MetS. Free triiodot hyronine/free thyroxine (FT3/FT4) and free triiodothyronine (FT3)) quartiles were posit ively associated with the increased odds ratio (OR) for MetS and dyslipidemia (hypertrigl yceridemia and low HDL-C), regardless of gender. In males, FT3 and FT3/FT4 quartil es were positively associated with the OR for central obesity, whereas FT4 quartil es were negatively associated; both FT3 and FT4 quartiles were positively associat ed with increased OR of hyperglycemia, while similar results were not observed in femal es. Interaction analysis indicated no significant effect of gender and TH interactions on risk of MetS. Conclusion: High FT3 and FT3/FT4 were strongly linked with MetS and dyslip idemia in our study, even in the euthyroid individuals. Tighter control of th yroid function was necessary for those with preexisting MetS component(s).

Published in Endocrine Connections

ISSN: 2049-3614 (Online)
Publisher: Bioscientifica
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: http://www.endocrineconnections.com/

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