Accelerated biological aging in COVID-19 patients

Xue Cao; Wenjuan Li; Ting Wang; Dongzhi Ran; Veronica Davalos; Laura Planas-Serra; Aurora Pujol; Manel Esteller; Xiaolin Wang; Huichuan Yu

doi:10.1038/s41467-022-29801-8

Nature Communications (Apr 2022)

Accelerated biological aging in COVID-19 patients

Xue Cao,
Wenjuan Li,
Ting Wang,
Dongzhi Ran,
Veronica Davalos,
Laura Planas-Serra,
Aurora Pujol,
Manel Esteller,
Xiaolin Wang,
Huichuan Yu

Affiliations

Xue Cao: Department of Oncology, Guizhou Provincial People’s Hospital
Wenjuan Li: Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital, Sun Yat-sen University
Ting Wang: Research & Development, Thermo Fisher Scientific Inc.
Dongzhi Ran: Department of Pharmacology, College of Medicine, University of Arizona
Veronica Davalos: Josep Carreras Leukaemia Research Institute (IJC)
Laura Planas-Serra: Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute (IDIBELL)
Aurora Pujol: Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute (IDIBELL)
Manel Esteller: Josep Carreras Leukaemia Research Institute (IJC)
Xiaolin Wang: Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital, Sun Yat-sen University
Huichuan Yu: Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital, Sun Yat-sen University

DOI: https://doi.org/10.1038/s41467-022-29801-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 7

Abstract

Read online

Age is a risk factor for SARS-CoV-2 infection and severe disease. Here the authors perform DNA methylation analyses in whole blood from COVID-19 patients using established epigenetic clocks and telomere length estimators, and describing correlations between epigenetic aging and the risk of SARS-CoV-2 infection and severe disease.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal