Role of cigarette smoke in the development of severe pneumonia and related research progress

Abstract

Cigarette smoke(CS) contains a large number of toxic and carcinogenic compounds. CS induces severe lung infections through different molecular and cellular mechanisms of alteration of respiratory tract structure, innate and adaptive immunity and microbiome homeostasis. CS is strongly associated with poor prognosis in corona virus disease 2019(COVID-19). The different mechanisms through which CS effects contribute to the understanding of the pathophysiology of CS-induced severe pneumonia and explore potential medicine.

Keywords

• cigarette smoke|pneumonia|immune system|microorganisms