Nature Communications (Jul 2016)
CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity
- Elad Jacoby,
- Sang M. Nguyen,
- Thomas J. Fountaine,
- Kathryn Welp,
- Berkley Gryder,
- Haiying Qin,
- Yinmeng Yang,
- Christopher D. Chien,
- Alix E. Seif,
- Haiyan Lei,
- Young K. Song,
- Javed Khan,
- Daniel W. Lee,
- Crystal L. Mackall,
- Rebecca A. Gardner,
- Michael C. Jensen,
- Jack F. Shern,
- Terry J. Fry
Affiliations
- Elad Jacoby
- Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Sang M. Nguyen
- Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Thomas J. Fountaine
- Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Kathryn Welp
- Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Berkley Gryder
- Genetics Branch, National Cancer Institute, National Institutes of Health
- Haiying Qin
- Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Yinmeng Yang
- Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Christopher D. Chien
- Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Alix E. Seif
- Division of Oncology, and Department of Pediatrics, The Children’s Hospital of Philadelphia, Perelman School of Medicine of the University of Pennsylvania
- Haiyan Lei
- Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Young K. Song
- Genetics Branch, National Cancer Institute, National Institutes of Health
- Javed Khan
- Genetics Branch, National Cancer Institute, National Institutes of Health
- Daniel W. Lee
- Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Crystal L. Mackall
- Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Rebecca A. Gardner
- and Department of Pediatrics, Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, University of Washington
- Michael C. Jensen
- and Department of Pediatrics, Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, University of Washington
- Jack F. Shern
- Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Terry J. Fry
- Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- DOI
- https://doi.org/10.1038/ncomms12320
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
CAR-T targeting CD19 have been successfully used in a variety of B-cell malignancies but patients may eventually relapse. Here, the authors show that CD19 CAR-T resistance in pre-B cell ALL can be due to the induction of a myeloid lineage switch through an epigenetic alterations in master regulators of B cell development.
