CYTOTOXIC ACTIVITY OF SELECTED LIBYAN MEDICINAL PLANTS ON HUMAN BREAST ADENOCARCINOMA CELL LINE (MCF-7)

Abstract

Three Libyan plants namely Ballota pseudodictamnus, Hedera helix, Thapsia garganica were tested for anticancer activity. The plants, collected from Aljabal-Al-Akhdar area of Libya in April 2010 were shed dried and subjected to Soxhlet extraction by methanol. Phytochemical screening indicated the presence of 2-deoxy sugars, flavonoids, saponins and tannins but absence of alkaloids in all three plants under investigation. Antiproliferative activity was performed breast adenocarcinoma cell line (MCF7). At the concentration of 100µg/mL, B. pseudodictamnus, T. garganica and H. helix showed 90, 60 and 5% cell death, respectively as compared to the control.

Keywords

• Antiproliferative
• Breast adenocarcinoma
• Cell l ine MCF-7