Cytotoxic and Anti-Inflammatory Effects of <i>Ent</i>-Kaurane Derivatives Isolated from the Alpine Plant <i>Sideritis hyssopifolia</i>
Axelle Aimond,
Kevin Calabro,
Coralie Audoin,
Elodie Olivier,
Mélody Dutot,
Pauline Buron,
Patrice Rat,
Olivier Laprévote,
Soizic Prado,
Emmanuel Roulland,
Olivier P. Thomas,
Grégory Genta-Jouve
Affiliations
Axelle Aimond
Laboratoire de Chimie-Toxicologie Analytique et Cellulaire (C-TAC) UMR CNRS 8038 CiTCoM Université Paris-Descartes, 4, Avenue de l’Observatoire, 75006 Paris, France
Kevin Calabro
Marine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway (NUI Galway), University Road, H91 TK33 Galway, Ireland
Coralie Audoin
Laboratoires Clarins, 5 Rue Ampère, 95300 Pontoise, France
Elodie Olivier
Laboratoire de Chimie-Toxicologie Analytique et Cellulaire (C-TAC) UMR CNRS 8038 CiTCoM Université Paris-Descartes, 4, Avenue de l’Observatoire, 75006 Paris, France
Mélody Dutot
Laboratoire de Chimie-Toxicologie Analytique et Cellulaire (C-TAC) UMR CNRS 8038 CiTCoM Université Paris-Descartes, 4, Avenue de l’Observatoire, 75006 Paris, France
Pauline Buron
Laboratoire de Chimie-Toxicologie Analytique et Cellulaire (C-TAC) UMR CNRS 8038 CiTCoM Université Paris-Descartes, 4, Avenue de l’Observatoire, 75006 Paris, France
Patrice Rat
Laboratoire de Chimie-Toxicologie Analytique et Cellulaire (C-TAC) UMR CNRS 8038 CiTCoM Université Paris-Descartes, 4, Avenue de l’Observatoire, 75006 Paris, France
Olivier Laprévote
Laboratoire de Chimie-Toxicologie Analytique et Cellulaire (C-TAC) UMR CNRS 8038 CiTCoM Université Paris-Descartes, 4, Avenue de l’Observatoire, 75006 Paris, France
Soizic Prado
Muséum National d’Histoire Naturelle, Unité Molécules de Communication et Adaptation des Micro-Organismes, UMR 7245, CP 54, 57 rue Cuvier, 75005 Paris, France
Emmanuel Roulland
Muséum National d’Histoire Naturelle, Unité Molécules de Communication et Adaptation des Micro-Organismes, UMR 7245, CP 54, 57 rue Cuvier, 75005 Paris, France
Olivier P. Thomas
Marine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway (NUI Galway), University Road, H91 TK33 Galway, Ireland
Grégory Genta-Jouve
Laboratoire de Chimie-Toxicologie Analytique et Cellulaire (C-TAC) UMR CNRS 8038 CiTCoM Université Paris-Descartes, 4, Avenue de l’Observatoire, 75006 Paris, France
This paper reports the isolation and structural characterization of four new ent-kaurane derivatives from the Lamiaceae plant Sideritis hyssopifolia. Planar structures and relative configurations were determined using both mass spectrometry and nuclear magnetic resonance (1D and 2D). Absolute configurations were determined by comparing experimental and theoretical electronic circular dichroism spectra. The cytotoxic and microbial activities of all new compounds were tested. Compounds that were non-cytotoxic were further evaluated for anti-inflammatory activity.
