Relevant mechanisms of MAIT cells involved in the pathogenesis of periodontitis

Xinrong Jiang; Xinrong Jiang; Qingtong Zhao; Qingtong Zhao; Zhanyu Huang; Zhanyu Huang; Fengyu Ma; Fengyu Ma; Kexiao Chen; Kexiao Chen; Zejian Li; Zejian Li

doi:10.3389/fcimb.2023.1104932

Frontiers in Cellular and Infection Microbiology (Feb 2023)

Relevant mechanisms of MAIT cells involved in the pathogenesis of periodontitis

Xinrong Jiang,
Xinrong Jiang,
Qingtong Zhao,
Qingtong Zhao,
Zhanyu Huang,
Zhanyu Huang,
Fengyu Ma,
Fengyu Ma,
Kexiao Chen,
Kexiao Chen,
Zejian Li,
Zejian Li

Affiliations

Xinrong Jiang: Hospital of Stomatology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangzhou, Guangdong, China
Xinrong Jiang: College of Stomatology, Jinan University, Guangzhou, Guangdong, China
Qingtong Zhao: Hospital of Stomatology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangzhou, Guangdong, China
Qingtong Zhao: Department of Stomatology, The Sixth Affiliated Hospital of Jinan University, Dongguan, Guangdong, China
Zhanyu Huang: Hospital of Stomatology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangzhou, Guangdong, China
Zhanyu Huang: College of Stomatology, Jinan University, Guangzhou, Guangdong, China
Fengyu Ma: Hospital of Stomatology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangzhou, Guangdong, China
Fengyu Ma: College of Stomatology, Jinan University, Guangzhou, Guangdong, China
Kexiao Chen: Hospital of Stomatology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangzhou, Guangdong, China
Kexiao Chen: College of Stomatology, Jinan University, Guangzhou, Guangdong, China
Zejian Li: Hospital of Stomatology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangzhou, Guangdong, China
Zejian Li: Chaoshan Hospital, The First Affiliated Hospital of Jinan University, Chaozhou, Guangdong, China

DOI: https://doi.org/10.3389/fcimb.2023.1104932
Journal volume & issue: Vol. 13

Abstract

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Mucosal-associated invariant T (MAIT) cells are a group of unconventional T cells that are abundant in the human body, recognize microbial-derived vitamin B metabolites presented by MHC class I-related protein 1 (MR1), and rapidly produce proinflammatory cytokines, which are widely involved in the immune response to various infectious diseases. In the oral mucosa, MAIT cells tend to accumulate near the mucosal basal lamina and are more inclined to secrete IL-17 when activated. Periodontitis is a group of diseases that manifests mainly as inflammation of the gums and resorption of the alveolar bone due to periodontal tissue invasion by plaque bacteria on the dental surface. The course of periodontitis is often accompanied by a T-cell-mediated immune response. This paper discussed the pathogenesis of periodontitis and the potential contribution of MAIT cells to periodontitis.

Published in Frontiers in Cellular and Infection Microbiology

ISSN: 2235-2988 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/Cellular-and-Infection-Microbiology

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Abstract

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