P53 orchestrates a complex symphony of cellular processes during oncosuppression

Abstract

We recently showed that the p53 tumor suppressor simultaneously governs numerous cellular processes in one model of transformation suppression. These findings suggest that p53-mediated tumor suppression relies on coordinated modulation of diverse cellular functions in a particular context, helping to explain why loss of the TP53 (tumor protein p53) gene is so prevalent in human cancers.

Keywords

• p53
• tumor suppression
• transformation
• cancer
• cell biology