Clinical Interventions in Aging (Apr 2023)
The Association Between Chronological Age and Dyslipidemia: A Cross-Sectional Study in Chinese Aged Population
Abstract
Qingyao Li,1,2,* Ying Jiang,2,* Anqi Song,2 Yun Li,1 Xinyi Xu,3 Renying Xu2 1Department of Preventive Medicine, School of Public Health, North China University of Science and Technology, Tangshan, People’s Republic of China; 2Department of Clinical Nutrition, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3School of Economics and Management, Shanghai Polytechnic University at Jing Hai Road, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Renying Xu, Department of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Tel +86-21-68383335, Email [email protected] Yun Li, Department of Preventive Medicine, School of Public Health, North China University of Science and Technology, Tangshan, People’s Republic of China, Tel +86-315-8805586, Email [email protected] and Aims: Dyslipidemia is obviously an important risk factor for cardiovascular diseases, which might further lead to disability and death in aged population. We thus performed the current study to evaluate the association between chronological age and dyslipidemia.Subjects and Methods: A total number of 59,716 Chinese aged population (31,174 men and 28,542 women, average age 67.8y) were included in the current study. Age and sex were abstracted from medical records. Height, body weight, and blood pressure were measured by trained nurses. Serum concentration of total cholesterol (TC) and total triglycerides were performed by enzyme-linked immunosorbent method after at least 8-h fast. Dyslipidemia was defined if total cholesterol≥ 5.7 mmol/L, or total triglycerides≥ 1.7 mmol/L, or self-reported history of dyslipidemia.Results: The prevalence of dyslipidemia was 50.4% in the current study population. Compared to the youngest age group (60– 64y), the adjusted odds ratio was 0.88 (95% CI: 0.84, 0.92), 0.77 (95% CI: 0.73, 0.81), 0.66 (95% CI: 0.61, 0.70), 0.55 (95% CI: 0.50, 0.59) for the participants who were 65 to 69, 70– 74, 75– 79, and ≥ 80 years old (p trend < 0.001). Excluding participants with low body weight and with overweight and obesity, with high blood pressure and history of hypertension, with high fasting blood glucose and history of diabetes, generated similar results with main analysis.Conclusion: Chronological age was closely associated with the risk of dyslipidemia in Chinese aged population.Keywords: age, total cholesterol, TC, total triglycerides, TG, dyslipidemia
