Trans-Cyclooctene Isomerization Catalyzed by Thiamine Degradation Products in Cell Culture Media

• Cathy A. Muste,
• Thomas C. Pickel,
• Philippe N. Bolduc,
• Emily A. Peterson,
• Chungang Gu,
• Brendon E. Cook

Affiliations

Cathy A. Muste

Drug Metabolism and Pharmacokinetics, Biogen, Cambridge, Massachusetts, United States

Thomas C. Pickel

ASO Development, Biogen, Cambridge, Massachusetts, United States

Philippe N. Bolduc

Medicinal Chemistry, Biogen, Cambridge, Massachusetts, United States

Emily A. Peterson

Medicinal Chemistry, Biogen, Cambridge, Massachusetts, United States

Chungang Gu

Drug Metabolism and Pharmacokinetics, Biogen, Cambridge, Massachusetts, United States

Brendon E. Cook

Biomarkers, Biogen, Cambridge, Massachusetts, United States