Communications Biology (Mar 2023)

PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment

  • C. Maresca,
  • A. Dello Stritto,
  • C. D’Angelo,
  • E. Petti,
  • A. Rizzo,
  • E. Vertecchi,
  • F. Berardinelli,
  • L. Bonanni,
  • A. Sgura,
  • A. Antoccia,
  • G. Graziani,
  • A. Biroccio,
  • E. Salvati

DOI
https://doi.org/10.1038/s42003-023-04596-6
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 12

Abstract

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The poly (ADP-ribose) polymerase (PARP1) interacts with the telomere factor TRF1 and loss of PARP1 results in telomere fragility and impairment of helicases -TRF1 complex assembly.