Can Glasgow score predict mortality in patients with chronic obstructive pulmonary disease with acute exacerbation?

Abstract

Background The study was planned to investigate the importance of Glasgow prognostic score (GPS) in cases that require hospitalization owing to chronic obstructive pulmonary disease (COPD) acute attack. Patients and methods The study retrospectively conducted 223 patients with acute exacerbation of COPD. Based on the data obtained from the files, the requirement of transfer to intensive care and death in hospital was considered as negative results. Results In total, 233 cases were involved in this study. A total of 194 (83.3%) of the patients were male, and 39 (16.7%) were female. GPS of 0, 1, and 2 were observed in 36, 112, and 85 patients, respectively. Cox regression analysis indicated that hospitalization in ICU (P=0.000, odds ratio: 7.45, confidence interval: 4.77–11.53%) and GPS 2 (P=0.11, odds ratio: 3.34, confidence interval: 1.314–8.52%) are independent risk factors for negative results of acute exacerbation. Survival times were shorter at significant levels in GPS 2 group. Conclusion It was found that elevated GPS values are associated with increased hospital mortality risk. GPS is a universally available, low-cost method and may be used as a prognostic marker for short-term hospital mortality in patients with acute exacerbation of COPD.

Keywords

• acute exacerbation
• chronic obstructive pulmonary disease
• mortality
• score