Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury

Beata Jablonska; Marcin Gierdalski; Li-Jin Chew; Teresa Hawley; Mackenzie Catron; Arturo Lichauco; Juan Cabrera-Luque; Tracy Yuen; David Rowitch; Vittorio Gallo

doi:10.1038/ncomms13866

Nature Communications (Dec 2016)

Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury

Beata Jablonska,
Marcin Gierdalski,
Li-Jin Chew,
Teresa Hawley,
Mackenzie Catron,
Arturo Lichauco,
Juan Cabrera-Luque,
Tracy Yuen,
David Rowitch,
Vittorio Gallo

Affiliations

Beata Jablonska: Center for Neuroscience Research, Children’s National Medical Center
Marcin Gierdalski: Division of Cardiac Surgery, Children’s National Medical Center
Li-Jin Chew: Center for Neuroscience Research, Children’s National Medical Center
Teresa Hawley: Flow Cytometry Core Facility, George Washington University
Mackenzie Catron: Center for Neuroscience Research, Children’s National Medical Center
Arturo Lichauco: Center for Neuroscience Research, Children’s National Medical Center
Juan Cabrera-Luque: Center for Genetic Medicine, Children’s National Medical Center
Tracy Yuen: Department of Pediatrics, Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco
David Rowitch: Department of Pediatrics, Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco
Vittorio Gallo: Center for Neuroscience Research, Children’s National Medical Center

DOI: https://doi.org/10.1038/ncomms13866
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 16

Abstract

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Oligodendrocyte progenitor cell (OPC) proliferation is crucial for regeneration after hypoxic lesions in mice, a model of diffuse white matter injury of premature infants. Here, the authors show that the histone deacetylase Sirt1 is a Cdk2-dependent mediator of OPC proliferation and OPC response to hypoxia.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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