Nature Communications (Dec 2016)
Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury
Abstract
Oligodendrocyte progenitor cell (OPC) proliferation is crucial for regeneration after hypoxic lesions in mice, a model of diffuse white matter injury of premature infants. Here, the authors show that the histone deacetylase Sirt1 is a Cdk2-dependent mediator of OPC proliferation and OPC response to hypoxia.