Nature Communications (Oct 2018)

Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion

  • Noumeira Hamoud,
  • Viviane Tran,
  • Takahiro Aimi,
  • Wataru Kakegawa,
  • Sylvie Lahaie,
  • Marie-Pier Thibault,
  • Ariane Pelletier,
  • G. William Wong,
  • In-San Kim,
  • Artur Kania,
  • Michisuke Yuzaki,
  • Michel Bouvier,
  • Jean-François Côté

DOI
https://doi.org/10.1038/s41467-018-06897-5
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 16

Abstract

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Myoblast fusion is an essential step in muscle growth and regeneration, and is regulated by the G-protein coupled receptor (GPCR) BAI3. Here Hamoud et al. show that the GPCR activity of BAI3 is spatiotemporally regulated during myoblast fusion, and identify C1qL4 and Stabilin-2 as, respectively, negative and positive regulators of its activity.