Nature Communications (Apr 2020)
Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma
- Akash Mitra,
- Miles C. Andrews,
- Whijae Roh,
- Marianna Petaccia De Macedo,
- Courtney W. Hudgens,
- Fernando Carapeto,
- Shailbala Singh,
- Alexandre Reuben,
- Feng Wang,
- Xizeng Mao,
- Xingzhi Song,
- Khalida Wani,
- Samantha Tippen,
- Kwok-Shing Ng,
- Aislyn Schalck,
- Donald A. Sakellariou-Thompson,
- Eveline Chen,
- Sangeetha M. Reddy,
- Christine N. Spencer,
- Diana Wiesnoski,
- Latasha D. Little,
- Curtis Gumbs,
- Zachary A. Cooper,
- Elizabeth M. Burton,
- Patrick Hwu,
- Michael A. Davies,
- Jianhua Zhang,
- Chantale Bernatchez,
- Nicholas Navin,
- Padmanee Sharma,
- James P. Allison,
- Jennifer A. Wargo,
- Cassian Yee,
- Michael T. Tetzlaff,
- Wen-Jen Hwu,
- Alexander J. Lazar,
- P. Andrew Futreal
Affiliations
- Akash Mitra
- Department of Genomic Medicine, University of Texas MD Anderson Cancer Center
- Miles C. Andrews
- Department of Surgical Oncology, University of Texas MD Anderson Cancer Center
- Whijae Roh
- The Broad Institute of MIT and Harvard
- Marianna Petaccia De Macedo
- Department of Pathology, University of Texas MD Anderson Cancer Center
- Courtney W. Hudgens
- Department of Pathology, University of Texas MD Anderson Cancer Center
- Fernando Carapeto
- Department of Pathology, University of Texas MD Anderson Cancer Center
- Shailbala Singh
- Department of Immunology, University of Texas MD Anderson Cancer Center
- Alexandre Reuben
- Department of Thoracic Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center
- Feng Wang
- Department of Genomic Medicine, University of Texas MD Anderson Cancer Center
- Xizeng Mao
- Department of Genomic Medicine, University of Texas MD Anderson Cancer Center
- Xingzhi Song
- Department of Genomic Medicine, University of Texas MD Anderson Cancer Center
- Khalida Wani
- Department of Pathology, University of Texas MD Anderson Cancer Center
- Samantha Tippen
- Department of Genomic Medicine, University of Texas MD Anderson Cancer Center
- Kwok-Shing Ng
- Institute for Personalized Cancer Therapy, University of Texas MD Anderson Cancer Center
- Aislyn Schalck
- Department of Genetics, University of Texas MD Anderson Cancer Center
- Donald A. Sakellariou-Thompson
- Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center
- Eveline Chen
- Department of Pathology, University of Texas MD Anderson Cancer Center
- Sangeetha M. Reddy
- Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center
- Christine N. Spencer
- Parker Institute for Cancer Immunotherapy
- Diana Wiesnoski
- Department of Genomic Medicine, University of Texas MD Anderson Cancer Center
- Latasha D. Little
- Department of Genomic Medicine, University of Texas MD Anderson Cancer Center
- Curtis Gumbs
- Department of Genomic Medicine, University of Texas MD Anderson Cancer Center
- Zachary A. Cooper
- AstraZeneca
- Elizabeth M. Burton
- Department of Surgical Oncology, University of Texas MD Anderson Cancer Center
- Patrick Hwu
- Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center
- Michael A. Davies
- Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center
- Jianhua Zhang
- Department of Genomic Medicine, University of Texas MD Anderson Cancer Center
- Chantale Bernatchez
- Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center
- Nicholas Navin
- Department of Genetics, University of Texas MD Anderson Cancer Center
- Padmanee Sharma
- Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center
- James P. Allison
- Department of Immunology, University of Texas MD Anderson Cancer Center
- Jennifer A. Wargo
- Department of Genomic Medicine, University of Texas MD Anderson Cancer Center
- Cassian Yee
- Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center
- Michael T. Tetzlaff
- Department of Pathology, University of Texas MD Anderson Cancer Center
- Wen-Jen Hwu
- Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center
- Alexander J. Lazar
- Department of Genomic Medicine, University of Texas MD Anderson Cancer Center
- P. Andrew Futreal
- Department of Genomic Medicine, University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-020-15538-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Immunotherapies now dominate the treatment landscape for melanoma, but why they only work in a subset of patients remains unclear. Here, the authors perform an immunogenomic analysis on 67 intratumor sub-regions of a PD-1 inhibitor resistant melanoma, and 2 additional metastases from a single patient, mapping the spatial relationships between genomic and immune heterogeneity at high resolution.
