Nature Communications (Oct 2022)
Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes
- Rupert L. Mayer,
- Rein Verbeke,
- Caroline Asselman,
- Ilke Aernout,
- Adillah Gul,
- Denzel Eggermont,
- Katie Boucher,
- Fabien Thery,
- Teresa M. Maia,
- Hans Demol,
- Ralf Gabriels,
- Lennart Martens,
- Christophe Bécavin,
- Stefaan C. De Smedt,
- Bart Vandekerckhove,
- Ine Lentacker,
- Francis Impens
Affiliations
- Rupert L. Mayer
- VIB-UGent Center for Medical Biotechnology, VIB
- Rein Verbeke
- Ghent Research Group on Nanomedicines, Ghent University
- Caroline Asselman
- VIB-UGent Center for Medical Biotechnology, VIB
- Ilke Aernout
- Ghent Research Group on Nanomedicines, Ghent University
- Adillah Gul
- VIB-UGent Center for Medical Biotechnology, VIB
- Denzel Eggermont
- VIB-UGent Center for Medical Biotechnology, VIB
- Katie Boucher
- VIB-UGent Center for Medical Biotechnology, VIB
- Fabien Thery
- VIB-UGent Center for Medical Biotechnology, VIB
- Teresa M. Maia
- VIB-UGent Center for Medical Biotechnology, VIB
- Hans Demol
- VIB-UGent Center for Medical Biotechnology, VIB
- Ralf Gabriels
- VIB-UGent Center for Medical Biotechnology, VIB
- Lennart Martens
- VIB-UGent Center for Medical Biotechnology, VIB
- Christophe Bécavin
- Université Côte d’Azur, CNRS, IPMC
- Stefaan C. De Smedt
- Ghent Research Group on Nanomedicines, Ghent University
- Bart Vandekerckhove
- Cancer Research Institute Ghent (CRIG)
- Ine Lentacker
- Ghent Research Group on Nanomedicines, Ghent University
- Francis Impens
- VIB-UGent Center for Medical Biotechnology, VIB
- DOI
- https://doi.org/10.1038/s41467-022-33721-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Currently, no approved vaccines for Listeria monocytogenes are available. Here, the authors use immunopeptidomics to map bacterial peptides presented on infected cells and identify antigens that, as mRNA vaccine, provide protection in mice.
