Langerhans Cell Histiocytosis in Children: Literature Review

Abstract

Relevant information on Langerhans cell histiocytosis development and course in children is presented. The current concepts of disease pathogenesis, principles of its severity evaluation, patients stratification into risk groups, as well as of clinical course features are described. Modern approaches to the disease treatment via targeted therapy are summarized and analyzed.

Keywords

• langerhans cell histiocytosis
• organs at risk
• target therapy