Frontiers in Cell and Developmental Biology (Oct 2021)

Autophagy and Aging: Roles in Skeletal Muscle, Eye, Brain and Hepatic Tissue

  • Ping Li,
  • Yuanzheng Ma,
  • Chengwei Yu,
  • Chengwei Yu,
  • Shoutong Wu,
  • Kai Wang,
  • Hongyang Yi,
  • Weizheng Liang

Journal volume & issue
Vol. 9


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Autophagy is an evolutionary conserved degradative process contributing to cytoplasm quality control, metabolic recycling and cell defense. Aging is a universal phenomenon characterized by the progressive accumulation of impaired molecular and reduced turnover of cellular components. Recent evidence suggests a unique role for autophagy in aging and age-related disease. Indeed, autophagic activity declines with age and enhanced autophagy may prevent the progression of many age-related diseases and prolong life span. All tissues experience changes during aging, while the role of autophagy in different tissues varies. This review summarizes the links between autophagy and aging in the whole organism and discusses the physiological and pathological roles of autophagy in the aging process in tissues such as skeletal muscle, eye, brain, and liver.