Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein

Valeria Calvaresi; Antoni G. Wrobel; Joanna Toporowska; Dietmar Hammerschmid; Katie J. Doores; Richard T. Bradshaw; Ricardo B. Parsons; Donald J. Benton; Chloë Roustan; Eamonn Reading; Michael H. Malim; Steve J. Gamblin; Argyris Politis

doi:10.1038/s41467-023-36745-0

Nature Communications (Mar 2023)

Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein

Valeria Calvaresi,
Antoni G. Wrobel,
Joanna Toporowska,
Dietmar Hammerschmid,
Katie J. Doores,
Richard T. Bradshaw,
Ricardo B. Parsons,
Donald J. Benton,
Chloë Roustan,
Eamonn Reading,
Michael H. Malim,
Steve J. Gamblin,
Argyris Politis

Affiliations

Valeria Calvaresi: Department of Chemistry, King’s College London
Antoni G. Wrobel: Structural Biology of Disease Processes Laboratory, The Francis Crick Institute
Joanna Toporowska: Department of Chemistry, King’s College London
Dietmar Hammerschmid: Department of Chemistry, King’s College London
Katie J. Doores: Department of Infectious Diseases, School of Immunology and Microbial Sciences, King’s College London
Richard T. Bradshaw: Department of Chemistry, King’s College London
Ricardo B. Parsons: Department of Chemistry, King’s College London
Donald J. Benton: Structural Biology of Disease Processes Laboratory, The Francis Crick Institute
Chloë Roustan: Structural Biology Science Technology Platform, The Francis Crick Institute
Eamonn Reading: Department of Chemistry, King’s College London
Michael H. Malim: Department of Infectious Diseases, School of Immunology and Microbial Sciences, King’s College London
Steve J. Gamblin: Structural Biology of Disease Processes Laboratory, The Francis Crick Institute
Argyris Politis: Department of Chemistry, King’s College London

DOI: https://doi.org/10.1038/s41467-023-36745-0
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 14

Abstract

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In this paper, the authors use hydrogen-deuterium exchange mass spectrometry to describe how the SARS-CoV-2 spike glycoprotein has evolved its structural dynamics features and receptor binding capability from the emergence of the original Wuhan isolate to the recent omicron variant. The findings reported shed light on the evolution of SARS-CoV-2 in the human population and the mechanisms of emergence of new variants.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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