A Comprehensive Overview of the Developments of Cdc25 Phosphatase Inhibitors
Ahmed Bakr Abdelwahab,
Eslam Reda El-Sawy,
Atef G. Hanna,
Denyse Bagrel,
Gilbert Kirsch
Affiliations
Ahmed Bakr Abdelwahab
Plant Advanced Technologies (PAT), 54500 Vandoeuvre-les-Nancy, France
Eslam Reda El-Sawy
National Research Centre, Chemistry of Natural Compounds Department, Dokki, Cairo 12622, Egypt
Atef G. Hanna
National Research Centre, Chemistry of Natural Compounds Department, Dokki, Cairo 12622, Egypt
Denyse Bagrel
Laboratoire Structure et Réactivité des Systèmes Moléculaires Complexes, UMR CNRS 7565, Université de Lorraine, Campus Bridoux, Rue du Général Delestraint, 57050 Metz, France
Gilbert Kirsch
Laboratoire Lorrain de Chimie Moléculaire (L.2.C.M.), Université de Lorraine, 57078 Metz, France
Cdc25 phosphatases have been considered promising targets for anticancer development due to the correlation of their overexpression with a wide variety of cancers. In the last two decades, the interest in this subject has considerably increased and many publications have been launched concerning this issue. An overview is constructed based on data analysis of the results of the previous publications covering the years from 1992 to 2021. Thus, the main objective of the current review is to report the chemical structures of Cdc25s inhibitors and answer the question, how to design an inhibitor with better efficacy and lower toxicity?
