Review on carbon dots: Synthesis and application in biology field
Xueting Li,
Lidong Yu,
Mingyue He,
Ce Chen,
Zewen Yu,
Shanshan Jiang,
Yi Wang,
Li Li,
Bingsheng Li,
Guixue Wang,
Aidong Shen,
Jianglin Fan
Affiliations
Xueting Li
School of Life Science and Technology Harbin Institute of Technology Harbin China
Lidong Yu
School of Life Science and Technology Harbin Institute of Technology Harbin China
Mingyue He
School of Life Science and Technology Harbin Institute of Technology Harbin China
Ce Chen
School of Life Science and Technology Harbin Institute of Technology Harbin China
Zewen Yu
School of Life Science and Technology Harbin Institute of Technology Harbin China
Shanshan Jiang
School of Life Science and Technology Harbin Institute of Technology Harbin China
Yi Wang
College of Basic Medical Sciences Chongqing Medical University Chongqing China
Li Li
School of Life Science and Technology Harbin Institute of Technology Harbin China
Bingsheng Li
Key Laboratory of UV Light Emitting Materials and Technology of Ministry of Education Northeast Normal University Changchun China
Guixue Wang
Key Laboratory for Biorheological Science and Technology Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants College of Bioengineering Chongqing University Chongqing China
Aidong Shen
Department of Electrical Engineering The City College of New York New York New York USA
Jianglin Fan
Guangdong Province Key Laboratory Southern China Institute of Large Animal Models for Biomedicine School of Biotechnology and Health Sciences Wuyi University Jiangmen China
Abstract As a multifunctional fluorescent nanomaterial, carbon dots (CDs) not only have small size, stable chemical properties, excellent photoluminescence characteristics, but also exhibit good biocompatibility and low toxicity. It has attracted considerable attention in the field of nanotechnology and biological science. CDs contain abundant functional groups on the surface, which not only retain part of the properties of raw materials, but also may have new photoelectric, catalytic, biomedical, and other functions. In this review, we systematically summarize the synthesis methods, modifications, optical properties, and main biological functions of CDs in recent years. The application of functionalized modified CDs in biological detection, biological imaging, photodynamic therapy, photothermal therapy, targeted therapy, drug delivery, gene delivery, protein delivery, and other biomedical fields is introduced. The latest progress of CDs with its own biomedical function in antioxidant, anti‐pathogen, and disease treatment is summarized. Finally, we discuss some problems in the practical application of CDs and look forward to the future development trend of self‐functional CDs combined with surface modification to achieve multimodal treatment of diseases.
