The advent of Industry 4.0 (I4.0) has pushed technology beyond its physical limits, making the process prone to errors and poorer performance. Whether it is about smart manufacturing where mass customization is envisaged, or collaborative human⁻robot engineering systems, the pyramid of process operation has changed to a matrix form and control is the backbone of all process elements. The paper gives a concise guideline as to how, when, where, and what to apply when it comes to choosing the most suitable control strategy as a function of multi-parameter objective optimization. Both proportional-integral-derivative (PID) and model predictive control (MPC) control are addressed in this context.