Nature Communications (Dec 2019)
Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice
- Shuangfei Ni,
- Zemin Ling,
- Xiao Wang,
- Yong Cao,
- Tianding Wu,
- Ruoxian Deng,
- Janet L. Crane,
- Richard Skolasky,
- Shadpour Demehri,
- Gehua Zhen,
- Amit Jain,
- Panfeng Wu,
- Dayu Pan,
- Bo Hu,
- Xiao Lyu,
- Yusheng Li,
- Hao Chen,
- Huabin Qi,
- Yun Guan,
- Xinzhong Dong,
- Mei Wan,
- Xuenong Zou,
- Hongbin Lu,
- Jianzhong Hu,
- Xu Cao
Affiliations
- Shuangfei Ni
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- Zemin Ling
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- Xiao Wang
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- Yong Cao
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- Tianding Wu
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- Ruoxian Deng
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- Janet L. Crane
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- Richard Skolasky
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- Shadpour Demehri
- Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine
- Gehua Zhen
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- Amit Jain
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- Panfeng Wu
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- Dayu Pan
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- Bo Hu
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- Xiao Lyu
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- Yusheng Li
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- Hao Chen
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- Huabin Qi
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- Yun Guan
- Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine
- Xinzhong Dong
- Department of Neuroscience, Neurosurgery, and Dermatology, Center of Sensory Biology, The Johns Hopkins University School of Medicine, Howard Hughes Medical Institute
- Mei Wan
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- Xuenong Zou
- Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, Department of Spinal Surgery, The First Affiliated Hospital of Sun Yat-sen University
- Hongbin Lu
- Department of Sports Medicine, Xiangya Hospital, Central South University
- Jianzhong Hu
- Department of Spine Surgery, Xiangya Hospital, Central South University
- Xu Cao
- Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-019-13476-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Spinal pain is a major clinical problem. Here the authors show that osteoclasts create porous area of endplates of the vertebrae and sensory innervation of porous endplates by Netrin-1 release from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice.
