A maladaptive feedback mechanism between the extracellular matrix and cytoskeleton contributes to hypertrophic cardiomyopathy pathophysiology

Helena M. Viola; Caitlyn Richworth; Tanya Solomon; Ian L. Chin; Henrietta Cserne Szappanos; Srinivasan Sundararaj; Dmitry Shishmarev; Marco G. Casarotto; Yu Suk Choi; Livia C. Hool

doi:10.1038/s42003-022-04278-9

Communications Biology (Jan 2023)

A maladaptive feedback mechanism between the extracellular matrix and cytoskeleton contributes to hypertrophic cardiomyopathy pathophysiology

Helena M. Viola,
Caitlyn Richworth,
Tanya Solomon,
Ian L. Chin,
Henrietta Cserne Szappanos,
Srinivasan Sundararaj,
Dmitry Shishmarev,
Marco G. Casarotto,
Yu Suk Choi,
Livia C. Hool

Affiliations

Helena M. Viola: School of Human Sciences, The University of Western Australia
Caitlyn Richworth: School of Human Sciences, The University of Western Australia
Tanya Solomon: School of Human Sciences, The University of Western Australia
Ian L. Chin: School of Human Sciences, The University of Western Australia
Henrietta Cserne Szappanos: School of Human Sciences, The University of Western Australia
Srinivasan Sundararaj: The Australian National University
Dmitry Shishmarev: The Australian National University
Marco G. Casarotto: The Australian National University
Yu Suk Choi: School of Human Sciences, The University of Western Australia
Livia C. Hool: School of Human Sciences, The University of Western Australia

DOI: https://doi.org/10.1038/s42003-022-04278-9
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 13

Abstract

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An in vitro model of hypertrophic cardiomyopathy is developed and used to identify a structural-functional link between the L-type calcium channel, mitochondria and the extracellular matrix.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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