Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory

Adam C. Frank; Shan Huang; Miou Zhou; Amos Gdalyahu; George Kastellakis; Tawnie K. Silva; Elaine Lu; Ximiao Wen; Panayiota Poirazi; Joshua T. Trachtenberg; Alcino J. Silva

doi:10.1038/s41467-017-02751-2

Nature Communications (Jan 2018)

Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory

Adam C. Frank,
Shan Huang,
Miou Zhou,
Amos Gdalyahu,
George Kastellakis,
Tawnie K. Silva,
Elaine Lu,
Ximiao Wen,
Panayiota Poirazi,
Joshua T. Trachtenberg,
Alcino J. Silva

Affiliations

Adam C. Frank: Department of Neurobiology; Integrative Center for Learning and Memory; Brain Research Institute, University of California
Shan Huang: Department of Neurobiology; Integrative Center for Learning and Memory; Brain Research Institute, University of California
Miou Zhou: Department of Neurobiology; Integrative Center for Learning and Memory; Brain Research Institute, University of California
Amos Gdalyahu: Department of Neurobiology; Integrative Center for Learning and Memory; Brain Research Institute, University of California
George Kastellakis: Institute for Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), GR
Tawnie K. Silva: Department of Neurobiology; Integrative Center for Learning and Memory; Brain Research Institute, University of California
Elaine Lu: Department of Neurobiology; Integrative Center for Learning and Memory; Brain Research Institute, University of California
Ximiao Wen: Department of Mechanical and Aerospace Engineering, University of California
Panayiota Poirazi: Institute for Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), GR
Joshua T. Trachtenberg: Department of Neurobiology; Integrative Center for Learning and Memory; Brain Research Institute, University of California
Alcino J. Silva: Department of Neurobiology; Integrative Center for Learning and Memory; Brain Research Institute, University of California

DOI: https://doi.org/10.1038/s41467-017-02751-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Structural remodeling of dendritic spines is thought to be a mechanism of memory storage. Here, the authors look at how spine turnover and clustering predict future learning and memory performance, and see that a genetically modified mouse with enhanced spine turnover has enhanced learning.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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