The <i>in vitro</i> neuroprotective activity of analogues of N-terminus substituted glyprolines

Abstract

In this work investigated the neuroprotective activity of analogues of substituted glyproline GZK-111 at the N-terminus in vitro. Oxidative stress caused by H2O2 (1.5 mM) led to significant decrease in the hippocampal cells HT-22 viability. The ethyl ester N-phenypropionyl-glycyl-proline (GZK-45) was effective at the concentrations up to 10–6 M in both experimental schemes. The compounds with N-acethyl (GZK-49) and N-capronoyl (GZK-46) fragments did not protective effect in both experimental schemes. GZK-45 also had protective effect in the 6-hydroxydopamine induced damage of SH-SY5Y neuroblastoma cells.

Keywords

• cyclo-l-prolylglycine
• oxydative stress
• 6-hydroxydopamine
• ht-22
• sh-sy5y
• gzk-45
• gzk-46
• gzk-49