Use of electrophoresis for the determination of protein polymorphisms: application to the study of isolated human populations

Abstract

Third factor of complements (C3), group specific component (Gc), properdin B factor (Bf), haptoglobin (Hp) and transferrin (Tf) polymorphisms were studied in a mountain communities samples from the Italian-French Alps. Electrophoresis was used to determine the seroprotein systems, since both traditional and high-resolution methods have proved to be valid tools in anthropogenetic investigations. Principal components analysis and maximum likelihood estimation were used to analyse the genetic relationships among populations.

Keywords

• Electrophoresis, seroproteins, mountain population