Nature Communications (Mar 2016)
Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus
- Quanjiang Ji,
- Peter J. Chen,
- Guangrong Qin,
- Xin Deng,
- Ziyang Hao,
- Zdzislaw Wawrzak,
- Won-Sik Yeo,
- Jenny Winjing Quang,
- Hoonsik Cho,
- Guan-Zheng Luo,
- Xiaocheng Weng,
- Qiancheng You,
- Chi-Hao Luan,
- Xiaojing Yang,
- Taeok Bae,
- Kunqian Yu,
- Hualiang Jiang,
- Chuan He
Affiliations
- Quanjiang Ji
- Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
- Peter J. Chen
- Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
- Guangrong Qin
- State Key Laboratory of Drug Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Xin Deng
- Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
- Ziyang Hao
- Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
- Zdzislaw Wawrzak
- Synchrotron Research Center, LS-CAT, Northwestern University
- Won-Sik Yeo
- Indiana University School of Medicine-Northwest
- Jenny Winjing Quang
- Department of Molecular Biosciences, High-Throughput Analysis Laboratory, Center for Structural Genomics of Infectious Diseases, Northwestern University
- Hoonsik Cho
- Indiana University School of Medicine-Northwest
- Guan-Zheng Luo
- Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
- Xiaocheng Weng
- Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
- Qiancheng You
- Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
- Chi-Hao Luan
- Department of Molecular Biosciences, High-Throughput Analysis Laboratory, Center for Structural Genomics of Infectious Diseases, Northwestern University
- Xiaojing Yang
- Department of Biochemistry and Molecular Biology, University of Chicago
- Taeok Bae
- Indiana University School of Medicine-Northwest
- Kunqian Yu
- State Key Laboratory of Drug Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Hualiang Jiang
- State Key Laboratory of Drug Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Chuan He
- Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
- DOI
- https://doi.org/10.1038/ncomms11000
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 11
Abstract
The WalKR signal transduction system is involved in extracellular signal recognition, but the details of this function are not well established. Here, the authors report the crystal structure of this two-component system alongside the characterisation of a small-molecule activator.
