Nature Communications (Jun 2017)
VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2
- Yao-Hui Gao,
- Zhao-Xia Wu,
- Li-Qi Xie,
- Cai-Xia Li,
- Yu-Qin Mao,
- Yan-Tao Duan,
- Bing Han,
- San-Feng Han,
- Yun Yu,
- Hao-Jie Lu,
- Peng-Yuan Yang,
- Tian-Rui Xu,
- Jing-Lin Xia,
- Guo-Qiang Chen,
- Li-Shun Wang
Affiliations
- Yao-Hui Gao
- Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University
- Zhao-Xia Wu
- Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University
- Li-Qi Xie
- Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University
- Cai-Xia Li
- Shanghai Universities E-Institute for Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
- Yu-Qin Mao
- Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University
- Yan-Tao Duan
- Shanghai Universities E-Institute for Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
- Bing Han
- Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University
- San-Feng Han
- Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University
- Yun Yu
- Shanghai Universities E-Institute for Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
- Hao-Jie Lu
- Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University
- Peng-Yuan Yang
- Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University
- Tian-Rui Xu
- Faculty of Life Science and Technology, Kunming University of Science and Technology
- Jing-Lin Xia
- Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University
- Guo-Qiang Chen
- Shanghai Universities E-Institute for Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
- Li-Shun Wang
- Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University
- DOI
- https://doi.org/10.1038/ncomms15337
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
The VHL tumour suppressor gene is lost in approximately 70% of clear cell renal cell carcinoma (ccRCC). In this study, the authors demonstrate that VHL loss in these tumours augments anthracyclines chemotherapy by down-regulation of ALDH2.
