Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells

Ting Zhang; Carsten Künne; Dong Ding; Stefan Günther; Xinyue Guo; Yonggang Zhou; Xuejun Yuan; Thomas Braun

doi:10.1038/s41467-022-34577-y

Nature Communications (Nov 2022)

Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells

Ting Zhang,
Carsten Künne,
Dong Ding,
Stefan Günther,
Xinyue Guo,
Yonggang Zhou,
Xuejun Yuan,
Thomas Braun

Affiliations

Ting Zhang: Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research
Carsten Künne: Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research
Dong Ding: Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research
Stefan Günther: Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research
Xinyue Guo: Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research
Yonggang Zhou: Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research
Xuejun Yuan: Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research
Thomas Braun: Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research

DOI: https://doi.org/10.1038/s41467-022-34577-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Suppression of transcription in S-phase is crucial to prevent genome instability. Zhang et al demonstrate that increase of H4K20me1 due to loss of Kmt5b cause genome instability in muscle stem cells, resulting in stem cell senescence but rhabdomyosarcoma formation when p53 is inactivated.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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