Consecutive isocyanide-based multicomponent reactions: synthesis of cyclic pentadepsipeptoids

Abstract

The synthesis of six cyclic depsipeptoids inspired by the natural depsipeptide sansalvamide A is described. An efficient and fast synthetic strategy was developed using a combination of consecutive isocyanide-based multicomponent reactions (Ugi and Passerini reactions). This methodology can be used to access a variety of cyclic oligodepsipeptoids.

Keywords

• depsipeptoids
• multicomponent reactions
• Passerini reaction
• sansalvamide A
• Ugi reaction