PREDICTION OF AN ADVERSE OUTCOME OF CORONARY HEART DISEASE IN PATIENTS SUFFERING FROM TYPE 2 DIABETES MELLITUS

Abstract

The aim of the study is to develop a model for predicting an adverse outcome of coronary heart disease (CHD) in patients suffering from type 2 diabetes mellitus (DM). Material and methods. A total of 135 patients have been examined. Among them there were 65 patients with CHD and DM type 2 and 70 patients with CHD but without DM type 2. The С677Т and А1298С polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene were determined by polymerase chain reaction. The endpoint was evaluated as having an adverse outcome of CHD after a one-year period of observation. Results. A model allowing to predict the probability of developing an adverse outcome of CHD in patients suffering from DM type 2 (sensitivity 84%, specificity 69%) has been constructed. Conclusions. The use of the regression equation will allow predicting more accurately the probability of developing an adverse outcome of CHD in patients suffering from DM type 2, and, as a result, choosing optimal tactics of such patients management.

Keywords

• coronary heart disease
• diabetes mellitus type 2
• polymorphic variants с677т and а1298с of the methylenetetrahydrofolate reductase gene
• prognosis