Artery Research (Nov 2015)

P3.7 ARTERIAL STIFFNESS IS ASSOCIATED WITH LOWER PERFORMANCE ON THE COGNITIVE TESTS AT DIFFERENT DOMAINS IN HYPERTENSIVE PATIENTS

  • Henrique Muela,
  • Valéria Costa-Hong,
  • Michel Machado,
  • Natalia Moraes,
  • Claudia Memoria,
  • Monica Yasuda,
  • Ricardo Nogueira,
  • Ayrton Massaro,
  • Edson Shu,
  • Ricardo Nitrini,
  • Luiz Bortolotto*

DOI
https://doi.org/10.1016/j.artres.2015.10.232
Journal volume & issue
Vol. 12

Abstract

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Background: Cognitive impairment and elevated arterial stiffness are described in patients with arterial hypertension (AH), but its correlations are not well studied. Objectives: To study the cognitive function at different domains and arterial properties in patients with AH stage 1 to 3 compared to normotensives and to evaluate the correlations between these variables. Methods: We evaluated 162 subjects, 42 normotensives (44.7±11yrs,69%male,88%white) and 120 patients with stage 1–3 AH (51±11yrs,46%male,69%white) under treatment. The global cognitive function was assessed by Mini Mental State Examination(MMSE) and Montreal Cognitive Assessment(MoCA). was done A validated comprehensive battery of neuropsychological tests assessed the following main cognitive areas:memory, language, visuoperceptual and visuospatial, praxia, gnosia, executive function, attention, judgment. Pulse wave velocity(PWV) was measured by Complior® device. Carotid properties were assessed by radiofrequency ultrasound(WTS®). Central arterial pressure and augmentation index(AIx) were obtained using applanation tonometry(Sphygmocor®). Results: Mean BP of the normotensive group (121.9±7/76.1±7 mmHg) was significantly lower than hypertensive patients (141.4±23/87.2±13 mmHg). Hypertensive group had worse performance in cognitive evaluation either by MMSE (27±2 vs. 28.6±1, p<0.05) or MoCA test (23.8±3 vs. 26.7±2, p<0.05). On the neuropsychological tests hypertensive patients had worse performance mainly in visuoperceptual and visuospatial capacities and executive function. On the multivariate regression analysis, the following independent associations were observed: PWV-memory, executive function and attention parameters; IMT-memory and executive function; AIx-all neuropsychological domains except memory. Conclusions: Cognitive impairment at different domains was more frequent in patients with different stages of AH. Arterial functional and structural properties were diversely associated with cognitive performance at different domains.