Nature Communications (Jul 2018)

Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm

  • Michael K. Strasser,
  • Philipp S. Hoppe,
  • Dirk Loeffler,
  • Konstantinos D. Kokkaliaris,
  • Timm Schroeder,
  • Fabian J. Theis,
  • Carsten Marr

DOI
https://doi.org/10.1038/s41467-018-05037-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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The timing of cell fate choices is usually unknown, because we have to rely on indirect evidence of their molecular basis. Here, the authors introduce a method to infer decision times from marker onset in cell genealogies, and find evidence refuting the paradigmatic PU.1/GATA1 cell fate switch.