Clinical Ophthalmology (Feb 2022)
Multifaceted Amblyopia Screening with blinq, 2WIN, and PDI Check
Abstract
Robert Arnold,1 Mario Angi2 1Alaska Blind Child Discovery, Alaska Children’s Eye and Strabismus, Anchorage, Alaska, 99508, USA; 2Senior Scientist, Department of Ophthalmology, University of Padua, Padua, Padua Province, ItalyCorrespondence: Robert Arnold, Alaska Blind Child Discovery, Alaska Children’s Eye and Strabismus, Office 280, 3500 Latouche Street, Anchorage, Alaska 99508, Tel +1-907 561-1917, Fax +1907 563-5373, Email [email protected]: Novel devices target different facets of amblyopia risk factors (ARFs). Through birefringence, the Rebion blinq assesses binocular foveation. The Adaptica 2WIN is a multiradial infrared photorefractor that also estimates ocular alignment. PDI Check is a forced-choice, dynamic near-vision game for the autostereoscopic Nintendo 3DS.Methods: New and returning patients to a pediatric ophthalmology clinic had concomitant confirmatory exams after all three vision screens had been validated with ROC curves, Bland–Altman plots, and Alaska Blind Child Discovery ellipsoid grades. Exam outcomes were classified by ARF visual acuity, strabismus, binocularity, and refractive errors following the 2021 AAPOS guidelines and Bosque–Hunter rubric for the blinq.Results: A total of 202 ethnically diverse students aged 10± 4 (4– 19) years, 33% treatment-naïve, had a high (58%) prevalence of ARFs. Linear logMAR visual acuity, intereye differences, stereo and three-cone color correlated well between PDI Check and exams. Mean score on the 2WIN matched sphero-cylinder exam with ellipsoid scoring was 2.1± 1.5. For AAPOS 2021 refractive plus strabismus, sensitivity/specificity for PDI Check was 68%/59%, 2WIN 72%/95%, and blinq 87%/32%. For the amblyopia or strabismus rubric, PDI Check was 79%/68%, 2WIN 56%/65%, and blinq 94%/37%.Conclusion: Each device had advantages and disadvantages in screening this cohort of older, high-prevalence students, many of whom had already been treated. Validation methods should cover more than just refraction, as the new 2021 AAPOS guidelines do.Keywords: amblyopia, vision screening, strabismus, validation
