mBio (Oct 2021)
HIV-1 Genomes Are Enriched in Memory CD4 <sup>+</sup> T-Cells with Short Half-Lives
- Vincent Morcilla,
- Charline Bacchus-Souffan,
- Katie Fisher,
- Bethany A. Horsburgh,
- Bonnie Hiener,
- Xiao Qian Wang,
- Timothy E. Schlub,
- Mark Fitch,
- Rebecca Hoh,
- Frederick M. Hecht,
- Jeffrey N. Martin,
- Steven G. Deeks,
- Marc K. Hellerstein,
- Joseph M. McCune,
- Peter W. Hunt,
- Sarah Palmer
Affiliations
- Vincent Morcilla
- Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia
- Charline Bacchus-Souffan
- Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA
- Katie Fisher
- ORCiD
- Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia
- Bethany A. Horsburgh
- Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia
- Bonnie Hiener
- Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia
- Xiao Qian Wang
- Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia
- Timothy E. Schlub
- Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia
- Mark Fitch
- Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, California, USA
- Rebecca Hoh
- Division of HIV, Infectious Diseases and Global Medicine, Department of Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA
- Frederick M. Hecht
- Division of HIV, Infectious Diseases and Global Medicine, Department of Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA
- Jeffrey N. Martin
- Division of HIV, Infectious Diseases and Global Medicine, Department of Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA
- Steven G. Deeks
- Division of HIV, Infectious Diseases and Global Medicine, Department of Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA
- Marc K. Hellerstein
- Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, California, USA
- Joseph M. McCune
- Global Health Innovative Technology Solutions/HIV Frontiers, Bill & Melinda Gates Foundation, Seattle, Washington, USA
- Peter W. Hunt
- Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA
- Sarah Palmer
- Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia
- DOI
- https://doi.org/10.1128/mBio.02447-21
- Journal volume & issue
-
Vol. 12,
no. 5
Abstract
The design of future HIV-1 curative therapies requires a more thorough understanding of the distribution of genetically intact HIV-1 within T-cell subsets as well as the cellular mechanisms that maintain this reservoir. These genetically intact and presumably replication-competent proviruses make up the latent HIV-1 reservoir.
