Short Cationic Peptidomimetic Antimicrobials

Rajesh Kuppusamy; Mark Willcox; David  StC. Black; Naresh Kumar

doi:10.3390/antibiotics8020044

Antibiotics (Apr 2019)

Short Cationic Peptidomimetic Antimicrobials

Rajesh Kuppusamy,
Mark Willcox,
David StC. Black,
Naresh Kumar

Affiliations

Rajesh Kuppusamy: School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia
Mark Willcox: School of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia
David StC. Black: School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia
Naresh Kumar: School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia

DOI: https://doi.org/10.3390/antibiotics8020044
Journal volume & issue: Vol. 8, no. 2
p. 44

Abstract

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The rapid growth of antimicrobial resistance against several frontline antibiotics has encouraged scientists worldwide to develop new alternatives with unique mechanisms of action. Antimicrobial peptides (AMPs) have attracted considerable interest due to their rapid killing and broad-spectrum activity. Peptidomimetics overcome some of the obstacles of AMPs such as high cost of synthesis, short half-life in vivo due to their susceptibility to proteolytic degradation, and issues with toxicity. This review will examine the development of short cationic peptidomimetics as antimicrobials.

Published in Antibiotics

ISSN: 2079-6382 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.mdpi.com/journal/antibiotics

About the journal

Abstract

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