Nature Communications (2019-07-01)

The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma

  • Shaodong Hong,
  • Dongbing Liu,
  • Shuzhen Luo,
  • Wenfeng Fang,
  • Jianhua Zhan,
  • Sha Fu,
  • Yaxiong Zhang,
  • Xuan Wu,
  • Huaqiang Zhou,
  • Xi Chen,
  • Gang Chen,
  • Zhonghan Zhang,
  • Qiufan Zheng,
  • Xiaobo Li,
  • Jinghao Chen,
  • Xingmin Liu,
  • Mengyue Lei,
  • Chen Ye,
  • Jian Wang,
  • Huanming Yang,
  • Xun Xu,
  • Shida Zhu,
  • Yunpeng Yang,
  • Yuanyuan Zhao,
  • Ningning Zhou,
  • Hongyun Zhao,
  • Yan Huang,
  • Lanjun Zhang,
  • Kui Wu,
  • Li Zhang

DOI
https://doi.org/10.1038/s41467-019-10902-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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The rare lung cancer subtype pulmonary lymphoepithelioma-like carcinoma is linked to Epstein-Barr virus infection. Here, the authors provide a mutational landscape for this cancer, showing a low burden of somatic mutations and high prevalence of copy number variations.