Nature Communications (Jul 2019)
The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma
- Shaodong Hong,
- Dongbing Liu,
- Shuzhen Luo,
- Wenfeng Fang,
- Jianhua Zhan,
- Sha Fu,
- Yaxiong Zhang,
- Xuan Wu,
- Huaqiang Zhou,
- Xi Chen,
- Gang Chen,
- Zhonghan Zhang,
- Qiufan Zheng,
- Xiaobo Li,
- Jinghao Chen,
- Xingmin Liu,
- Mengyue Lei,
- Chen Ye,
- Jian Wang,
- Huanming Yang,
- Xun Xu,
- Shida Zhu,
- Yunpeng Yang,
- Yuanyuan Zhao,
- Ningning Zhou,
- Hongyun Zhao,
- Yan Huang,
- Lanjun Zhang,
- Kui Wu,
- Li Zhang
Affiliations
- Shaodong Hong
- Department of Medical Oncology, Sun Yat-sen University Cancer Center
- Dongbing Liu
- BGI-Shenzhen
- Shuzhen Luo
- BGI-Shenzhen
- Wenfeng Fang
- Department of Medical Oncology, Sun Yat-sen University Cancer Center
- Jianhua Zhan
- Department of Medical Oncology, Sun Yat-sen University Cancer Center
- Sha Fu
- Department of Pathology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Yaxiong Zhang
- Department of Medical Oncology, Sun Yat-sen University Cancer Center
- Xuan Wu
- Department of Medical Oncology, Sun Yat-sen University Cancer Center
- Huaqiang Zhou
- Department of Medical Oncology, Sun Yat-sen University Cancer Center
- Xi Chen
- Department of Medical Oncology, Sun Yat-sen University Cancer Center
- Gang Chen
- Department of Medical Oncology, Sun Yat-sen University Cancer Center
- Zhonghan Zhang
- Department of Medical Oncology, Sun Yat-sen University Cancer Center
- Qiufan Zheng
- Department of Medical Oncology, Sun Yat-sen University Cancer Center
- Xiaobo Li
- BGI-Shenzhen
- Jinghao Chen
- BGI-Shenzhen
- Xingmin Liu
- BGI-Shenzhen
- Mengyue Lei
- BGI-Shenzhen
- Chen Ye
- BGI-Shenzhen
- Jian Wang
- BGI-Shenzhen
- Huanming Yang
- BGI-Shenzhen
- Xun Xu
- BGI-Shenzhen
- Shida Zhu
- BGI-Shenzhen
- Yunpeng Yang
- Department of Medical Oncology, Sun Yat-sen University Cancer Center
- Yuanyuan Zhao
- Department of Medical Oncology, Sun Yat-sen University Cancer Center
- Ningning Zhou
- Department of Medical Oncology, Sun Yat-sen University Cancer Center
- Hongyun Zhao
- Department of Medical Oncology, Sun Yat-sen University Cancer Center
- Yan Huang
- Department of Medical Oncology, Sun Yat-sen University Cancer Center
- Lanjun Zhang
- State Key Laboratory of Oncology in South China
- Kui Wu
- BGI-Shenzhen
- Li Zhang
- Department of Medical Oncology, Sun Yat-sen University Cancer Center
- DOI
- https://doi.org/10.1038/s41467-019-10902-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
The rare lung cancer subtype pulmonary lymphoepithelioma-like carcinoma is linked to Epstein-Barr virus infection. Here, the authors provide a mutational landscape for this cancer, showing a low burden of somatic mutations and high prevalence of copy number variations.
