Hyperimmunoglobulin E syndrome in two siblings

Abstract

Hyperimmunoglobulin E recurrent infection syndrome (HIES) is characterized by recurrent skin and lung infections, eczema, elevated serum immunoglobulin E (IgE) levels (>2000 IU/mL), various connective tissue, skeletal, and vascular abnormalities.1 We describe herein two brothers with HIES and documented the complications and management of such involvement.

Keywords

• hyper-IgE syndrome, atopic dermatitis, primary immunodeficiency, infection.