Акушерство, гинекология и репродукция (Jun 2016)
LEVELS OF GLIAL FIBRILLARY ACIDIC PROTEIN IN SERUM AFTER CEREBRAL ISCHEMIA IN THE NEONATAL PERIOD
Abstract
Investigation of dynamics of serum glial fibrillary acid protein (GFAP) concentration within the first 6 months of life of neonates with cerebral ischemia has both scientific and practical implications. Materials and methods. 49 neonates with perinatal hypoxic-ischemic lesion of the CNS and gestational age 32-41 weeks have been examinedbetween the ages of 1 and 24 weeks of life. 28 healthy term infants comprised the control group. The neonates were assigned to one of the following groups: babies with Apgar score of 1-3 points one minute after birth (group A 1-3), 4-6 points (group А 4-6) and 7-9 points (group А 7-9); neonates with gestational age (GA) GA 32-33 weeks, GA 34-36 weeks and GA 37-40 weeks; newborns with intraventricular hemorrhages (IVH group) and periventricular leukomalacia (PVL group). Quantitative analysis of serum GFAP was carried out using the immunoenzymatic assay (IEA). Results. We havefound a significantly increases serum GFAP concentration among neonates aged one week in groups А 1-3, А 4-6 and А 7-9 as compared to control group. Serum GFAP concentration in infants of the GA 32-33 group was significantly higher compared to the GA 34-36 and GA 37-41 groups and control group. The differences between the IVH group and PVL group were not significant during the first week of life although the mean GFAP values were somewhat lower in the PVL group compared to the IVH group. We have found the phenomenon of delayed increase of the GFAP concentration in neonates aged 3 weeks. Conclusion. Determination of serum GFAP concentration can be used for the verification of severity and type of CNS lesion in newborns at different gestational ages.
