SUMOylation in Glioblastoma: A Novel Therapeutic Target

Brandon  M. Fox; Andrew Janssen; Dagoberto Estevez-Ordonez; Florian Gessler; Nunzio Vicario; Gustavo Chagoya; Galal Elsayed; Houman Sotoudeh; William Stetler; Gregory  K. Friedman; Joshua  D. Bernstock

doi:10.3390/ijms20081853

International Journal of Molecular Sciences (Apr 2019)

SUMOylation in Glioblastoma: A Novel Therapeutic Target

Brandon M. Fox,
Andrew Janssen,
Dagoberto Estevez-Ordonez,
Florian Gessler,
Nunzio Vicario,
Gustavo Chagoya,
Galal Elsayed,
Houman Sotoudeh,
William Stetler,
Gregory K. Friedman,
Joshua D. Bernstock

Affiliations

Brandon M. Fox: Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA
Andrew Janssen: Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA
Dagoberto Estevez-Ordonez: Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA
Florian Gessler: Department of Neurosurgery, University Hospital Frankfurt, Goethe-University, Schleusenweg 2-16, 60528 Frankfurt, Germany
Nunzio Vicario: Department of Biomedical and Biotechnological Sciences, Physiology Section, University of Catania, Via S. Sofia n. 97, Torre Biologica, 95123 Catania, Italy
Gustavo Chagoya: Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA
Galal Elsayed: Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA
Houman Sotoudeh: Division of Neuroradiology, Department of Radiology, University of Alabama at Birmingham, Jefferson Tower N419—619 19th Street South, Birmingham, AL 35223, USA
William Stetler: Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA
Gregory K. Friedman: Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA
Joshua D. Bernstock: Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA

DOI: https://doi.org/10.3390/ijms20081853
Journal volume & issue: Vol. 20, no. 8
p. 1853

Abstract

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Protein SUMOylation is a dynamic post-translational modification which is involved in a diverse set of physiologic processes throughout the cell. Of note, SUMOylation also plays a role in the pathobiology of a myriad of cancers, one of which is glioblastoma (GBM). Accordingly, herein, we review core aspects of SUMOylation as it relates to GBM and in so doing highlight putative methods/modalities capable of therapeutically engaging the pathway for treatment of this deadly neoplasm.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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Abstract

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