Redox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate

Weam S. Shahin; Shima O. Ebed; Scott R. Tyler; Branko Miljkovic; Soon H. Choi; Yulong Zhang; Weihong Zhou; Idil A. Evans; Charles Yeaman; John F. Engelhardt

doi:10.1038/s41467-023-36174-z

Nature Communications (Jan 2023)

Redox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate

Weam S. Shahin,
Shima O. Ebed,
Scott R. Tyler,
Branko Miljkovic,
Soon H. Choi,
Yulong Zhang,
Weihong Zhou,
Idil A. Evans,
Charles Yeaman,
John F. Engelhardt

Affiliations

Weam S. Shahin: Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa
Shima O. Ebed: Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa
Scott R. Tyler: Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa
Branko Miljkovic: Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa
Soon H. Choi: Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa
Yulong Zhang: Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa
Weihong Zhou: Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa
Idil A. Evans: Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa
Charles Yeaman: Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa
John F. Engelhardt: Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa

DOI: https://doi.org/10.1038/s41467-023-36174-z
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 13

Abstract

Read online

How reactive oxygen species regulate neuronal stem cell (NSC) behavior is poorly understood. Here, the authors report that Ncf1-dependent oxidation of Igfbp2 cystines represses DNA repair networks to regulate NSC self-renewal and cell fate decisions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal