Nature Communications (Oct 2019)
RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype
- Demin Cai,
- Junjian Wang,
- Bei Gao,
- Jin Li,
- Feng Wu,
- June X. Zou,
- Jianzhen Xu,
- Yuqian Jiang,
- Hongye Zou,
- Zenghong Huang,
- Alexander D. Borowsky,
- Richard J. Bold,
- Primo N. Lara,
- Jian Jian Li,
- Xinbin Chen,
- Kit S. Lam,
- Ka-Fai To,
- Hsing-Jien Kung,
- Oliver Fiehn,
- Ruqian Zhao,
- Ronald M. Evans,
- Hong-Wu Chen
Affiliations
- Demin Cai
- Department of Biochemistry and Molecular Medicine, University of California Davis
- Junjian Wang
- Department of Biochemistry and Molecular Medicine, University of California Davis
- Bei Gao
- West Coast Metabolomics Center, University of California Davis
- Jin Li
- Department of Biochemistry and Molecular Medicine, University of California Davis
- Feng Wu
- Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong
- June X. Zou
- Department of Biochemistry and Molecular Medicine, University of California Davis
- Jianzhen Xu
- Shantou University Medical College
- Yuqian Jiang
- Department of Biochemistry and Molecular Medicine, University of California Davis
- Hongye Zou
- Department of Biochemistry and Molecular Medicine, University of California Davis
- Zenghong Huang
- Department of Biochemistry and Molecular Medicine, University of California Davis
- Alexander D. Borowsky
- Department of Pathology and Laboratory Medicine, University of California Davis
- Richard J. Bold
- Department of Surgery, University of California Davis
- Primo N. Lara
- Comprehensive Cancer Center, University of California Davis
- Jian Jian Li
- Department of Radiation Oncology, University of California Davis
- Xinbin Chen
- Comprehensive Cancer Center, University of California Davis
- Kit S. Lam
- Department of Biochemistry and Molecular Medicine, University of California Davis
- Ka-Fai To
- Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong
- Hsing-Jien Kung
- Department of Biochemistry and Molecular Medicine, University of California Davis
- Oliver Fiehn
- West Coast Metabolomics Center, University of California Davis
- Ruqian Zhao
- MOE Joint International Research Laboratory of Animal Health and Food Safety, Nanjing Agricultural University
- Ronald M. Evans
- Gene Expression Laboratory, Salk Institute, Howard Hughes Medical Institute, Salk Institute
- Hong-Wu Chen
- Department of Biochemistry and Molecular Medicine, University of California Davis
- DOI
- https://doi.org/10.1038/s41467-019-12529-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Enhanced cholesterol biosynthesis is associated with cancer progression. Here the authors identify the nuclear receptor RORγ as a novel master regulator of cholesterol metabolism in triple negative breast cancer (TNBC) and find that RORγ small-molecule antagonists induce tumor regression in patient-derived xenografts and immunocompetent mouse models.
