Structural insights into the peptide selectivity and activation of human neuromedin U receptors

Chongzhao You; Yumu Zhang; Peiyu Xu; Sijie Huang; Wanchao Yin; H. Eric Xu; Yi Jiang

doi:10.1038/s41467-022-29683-w

Nature Communications (Apr 2022)

Structural insights into the peptide selectivity and activation of human neuromedin U receptors

Chongzhao You,
Yumu Zhang,
Peiyu Xu,
Sijie Huang,
Wanchao Yin,
H. Eric Xu,
Yi Jiang

Affiliations

Chongzhao You: The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Yumu Zhang: The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Peiyu Xu: The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Sijie Huang: The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Wanchao Yin: The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
H. Eric Xu: The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Yi Jiang: The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-022-29683-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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Neuromedin U receptors (NMURs) are potential drug targets for obesity and inflammatory disorders. Here, the authors report structural basis for neuromedin recognition and activation mechanism of NMURs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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